Patients’ diabetic ulcers were randomized into a placebo group (n = 51), a 0.001% (w/v) FGF2 treatment group (n = 49) and a 0.01% (w/v) FGF2 treatment group (n = 50), with the primary outcome being the percentage of patients showing a 75% or greater reduction in the area of ulcer. The gene discussed is FGF2; the disease is ulcer disease.