Thus, when FGF-2 mRNA levels were analysed in a cohort of breast cancer patients, elevated expression of FGF-2 mRNA correlated with a good prognostic outcome, the opposite of the result expected from the naïve perspective that “FGF2 = uncontrolled growth + angiogenesis = cancer” (Anandappa et al., 1994). This evidence concerns the gene FGF2 and breast carcinoma.