For the NOD2 SNPs found to be associated with leprosy among Chinese patients (Zhang, 2009) (40), only the rs9302752 SNP was replicated in 474 samples family based from Vietnamese with PB and MB leprosy (N = 188 and N = 286, respectively) suggesting risk for development of severe form of leprosy (MB) (P = 0.014; OR = 1.27; IC = 1.27–1.58) (43). This evidence concerns the gene NOD2 and leprosy.