TNF and leprosy: The genetic analysis of a study developed with a population of Nepal (933 leprosy patients), which examined polymorphisms in the TNF and MBL genes showed the MBL-G161A variant associated with protection against LL, and identified a polymorphism associated with low MBL levels (homozygosity of MBL-G161A), which was associated with a reduced risk of LL when compared with TT leprosy (OR = 0.33; CI95% = 0.12–0.85, P = 0.010) (25).