Furthermore, this study reported that the EC50 level for IL-2 induction of STAT5 phosphorylation between T1D patients and healthy subjects was similar, and there is a response gap between Tregs and CD4+ memory T cells in patients with T1D, which may be important in determining an effective therapeutic window for LD IL-2 for treatment of T1D (62). The gene discussed is CD4; the disease is type 1 diabetes mellitus.