APP and early-onset autosomal dominant Alzheimer disease: Accumulation of oligomers and β-amyloid peptides (Aβ), behavioral deficits and plaque pathology have been upturned in the brains of old and middle-aged APP/PS1 Alzheimer’s disease transgenic mice with the oral dispensation of a semi-purified extract of the root of W. somnifera mainly involving withanosides and withanolides (Sehgal et al., 2012).