TSC2 and non-small cell lung carcinoma: In a study of non-small cell lung cancer, it was found that p-Akt(Thr308), but not p-Akt(Ser43) correlated with phosphorylation of three downstream substrates (PRAS40, TSC2, and TBC1D4), leading the authors to suggest that p-Akt(Thr308) represents a better measure of Akt activity in these tumors (181).