The generation of the phospho-specific Sin-1 antibodies, along with the discovery that mutation of the Sin1 phosphorylation sites occurs naturally in ovarian and skin cancers and abrogates the negative control on Akt activity (73), could be helpful in determining the mechanisms for the positive association between p-Akt(Ser473) and Sin1 in thyroid cancers. This evidence concerns the gene MAPKAP1 and skin cancer.