BMP7 and hereditary pheochromocytoma-paraganglioma: MENX pheochromocytomas also overexpress secreted BMP7 (Bone Morphogenic Protein 7); this parallels elevated immunoreactivity for BMP7 in human pheochromocytoma samples, detected in 72% of 184 tumor samples on tissue microarray (150 pheochromocytomas and 34 paragangliomas) (142), and BMP7 knockdown was demonstrated to promote proliferation, migration, and invasion primary cultures of MENX-derived pheochromocytomas.