The PI3K/Akt pathway is perhaps less well studied in intestinal NET than P-NET, however, in a cohort of 48 well-differentiated small intestinal NET (SI-NET), approximately one-third were found to have genetic alterations in the PI3K/Akt/mTOR pathway, with amplification of Akt1/2 being the most common anomaly in this pathway (171). This evidence concerns the gene PIK3CA and small intestine neuroendocrine neoplasm.