AKT1 and cancer: The Cancer Genome Atlas Research Network (30) compiled an RPPA data set including p-Akt(Thr308) and p-Akt(Ser473) to show that Akt is activated in RAS-like papillary thyroid tumors, however from these data, depicted as a heat map, it can be seen that Akt is not always highly phosphorylated on both sites.