By contrast, also using western blotting, Miyakawa et al. (43) compared seven matched pairs of papillary thyroid cancer and adjacent normal tissue and found total Akt levels unchanged, but there was significantly higher p-Akt in tumor tissue compared to surrounding tissues (five of seven pairs), with elevated levels of activated downstream targets p-Bad and p-p70S6K. Here, AKT1 is linked to thyroid gland papillary carcinoma.