AKT1 and pituitary gland adenoma: In particular, Eps8 (Epidermal Growth Factor Receptor Pathway Substrate 8), which signals downstream of these receptors, promoted cell survival through modulation of Akt activity in Eps8-overexpressing LβT2 gonadotrope cells in vitro, and immunoblotting demonstrated that both p-Akt(Thr308) and Eps8 are overexpressed in human pituitary adenomas (101).