Vasco et al. (48) reported that invasive regions of papillary and thyroid cancer were characterized by both nuclear p-Akt and nuclear exclusion of p27KIP1 and used a human papillary thyroid cancer cell line (NPA) to link p-Akt and cytoplasmic exclusion of p27KIP1 with invasive capacity in a transwell assay. This evidence concerns the gene CDKN1B and thyroid gland carcinoma.