However, Tamburrino et al. (68) found significant correlations between p-Akt(Ser473) and p-ERK staining and Pennelli et al. (75) also remarked on the preferential activation of the PI3K/Akt pathway, detected as high levels of p-Akt(Ser473) on western blotting in medullary thyroid carcinoma cases which had mutant RAS. Here, AKT1 is linked to medullary thyroid gland carcinoma.