AKT1 and adrenal cortex carcinoma: Altered β-catenin expression may also regulate Akt activation in these tumors: β-catenin expression is known to be altered in 20% of ACC, and knockdown of β-catenin in human ACC cells in vitro decreases Akt phosphorylation (126), although no correlation was seen between p-Akt(Ser473) and β-catenin immunostaining in human tumors (85).