AKT1 and cancer: p-Akt(Ser473) expression was strongly associated with p-mTOR and p-p70S6K in a series of 49 cancers, suggesting that the Akt/mTOR pathway is active in these tumors, and is therefore potentially amenable to therapy (66), but there was no association between p-Akt expression and prognosis or clinicopathological factors (66).