AKT1 and thyroid gland papillary carcinoma: By contrast to these studies, Zafón et al. (60) did not find any difference in cytoplasmic or nuclear p-Akt(Ser473) staining between papillary thyroid cancers with or without associated lymph node metastases at the time of diagnosis, even though the group with associated metastases had a greater proportion overexpressing RET or EGFR.