INS and obesity due to melanocortin 4 receptor deficiency: T-cells are known to play a role in inflammatory myopathies (Choi et al., 2009; Crescioli et al., 2012), muscular dystrophies (Spencer et al., 2001; Choi et al., 2009; Madaro and Bouche, 2014), and obesity-related muscle fat accumulation and insulin resistance (Khan et al., 2015).