INS and chronic obstructive pulmonary disease: Accordingly, alterations in mitochondrial morphology and function are frequently associated with atrophying muscles in aging (see Section “The Role of Disrupted Mitochondria Quality Control Pathways in Aging Sarcopenia”) as well as in several wasting conditions such as burn injury (Porter et al., 2013), intensive care unit-acquired weakness (Friedrich et al., 2015), insulin resistance (Crescenzo et al., 2014), chronic obstructive pulmonary disease (COPD) (Mathur et al., 2014), cancer cachexia (Antunes et al., 2014), and in different neuromuscular disorders (Katsetos et al., 2013).