In fact, it has been described that Aβ peptides are able to induce JNK activation, as it has been found in vitro that p JNK increases after treatment with Aβ in primary cortical and hippocampal cultures from C57BL/6 mice, in primary cortical cell cultures from Wistar rat and in SH-SY5Y neuroblastoma cells (Morishima et al., 2001; Suwanna et al., 2014; Xu et al., 2015). This evidence concerns the gene MAPK8 and neuroblastoma.