APOA1 and coronary artery disorder: On the other hand, several research labs identified MPO as a major enzymatic factor that chemically modifies apoA-I into various oxidized forms (e.g., chloro-, bromo-, oxy-, nitro-, nitrile-, carbamyl-, etc.)that are abundant in atherosclerotic lesions and detectable in plasma of CAD patients (Heinecke, 2003; Pennathur et al., 2004; Zheng et al., 2004; Nicholls et al., 2005; Undurti et al., 2009; Shao et al., 2012).