KNG1 and ischemia: The B2R is constitutively expressed in many tissues, and its activation is believed to play a major role in the cardioprotective effects of BK during hypertension and other clinical and experimental conditions, such as cardiac failure, ischemia, myocardial infarction, and pulmonary hypertension (Heitsch, 2003; Veeravalli and Akula, 2004; Xi et al., 2008; Marketou et al., 2010; Sharma and Al-Banoon, 2012; Potier et al., 2013).