More recently, Corsetti et al. (2015) showed that an N-terminal truncated tau species found in AD individuals can induce deregulated mitophagy by aberrant recruitment of Parkin that result in excessive mitochondrial turnover, synaptic deterioration and neuronal death, thus providing a Parkin-related mechanism in the pathogenesis of AD. The gene discussed is PRKN; the disease is Alzheimer disease.