PRKN and Parkinson disease: Notably, we and others have found that a wide variety of PD-linked stressors, including those that produce oxidative and nitrosative stress, induce Parkin solubility alterations and thereby its aggregation in a manner that is analogous to that brought about by several of its missense mutations (Winklhofer et al., 2003; LaVoie et al., 2005; Wang et al., 2005a).