Nlgn2 null mice have been assessed in multiple behavioral tests and found to demonstrate phenotypes suggestive of anxiety (Blundell et al., 2009; Wohr et al., 2013; Babaev et al., 2015) or autism spectrum disorder (ASD; Hines et al., 2008; Kohl et al., 2015; Liang et al., 2015). This evidence concerns the gene NLGN2 and Anxiety.