Alterations in SERT expression and function have been implicated in a range of neurobehavioral disorders including anxiety, depression, obsessive-compulsive disorder and autism (Lesch et al., 1996; Ozaki et al., 2003; Sutcliffe et al., 2005; Homberg and Lesch, 2011; Voyiaziakis et al., 2011). The gene discussed is SLC6A4; the disease is autism.