Calabrese et al. proposed the neurotrophin brain-derived neurotrophic factor (BDNF) as a bridge between increased levels of pro-inflammatory cytokines and impaired neuroplasticity while the contribution of Cattaneo et al. is centered on epigenetics mechanisms that, by altering inflammation-immune systems and neuronal plasticity, may increase vulnerability to develop psychiatric disorders following early life stressful events. This evidence concerns the gene BDNF and psychiatric disorder.