Calreticulin—increased here by 1.89-fold in the SMA motor neurons compared to the control motor neurons (Supplementary Table 1A)—was previously shown to be increased in SMA mouse muscle, SMA fibroblasts and SMA patient muscle biopsies by ~1.5-fold, on average, although considerable variability between patients was noted (Mutsaers et al., 2013). The gene discussed is CALR; the disease is proximal spinal muscular atrophy.