In patients with DYT11-positive myoclonus-dystonia syndrome (van der Salm et al., 2009), the authors hypothesized that the mutation associated with the disease, SGCE gene, could have caused changes in membrane properties or ion channels, leading to asynchronous discharge timing of spinal motorneurons by the descending corticospinal activity. The gene discussed is SGCE; the disease is myoclonus-dystonia syndrome.