CD4-AsiCs bearing siRNAs that recognized HIV gag and vif or host CCR5 were specifically taken up by CD4+ cells, knocked down genes expression, and inhibited HIV infection in primary CD4+ T cells and in the female genital tract of humanized mice [122, 123] and at the same time do not activate lymphocytes or stimulate innate immunity [122, 123]. The gene discussed is CD4; the disease is HIV infectious disease.