Recently, it was reported that KLF5 is highly expressed in cardiac fibroblasts under pressure overload and contributes to the development of cardiac hypertrophy and fibrosis through the release of several growth factors including TGF-β, platelet-derived growth factor (PDGF), and insulin-like growth factors (IGF) [24, 25]. This evidence concerns the gene TGFB1 and cardiac hypertrophy.