ACE and cutaneous mastocytosis: For decades, antiepileptic drugs (e.g., topiramate, divalproex sodium), antihypertensive agents (e.g., beta blockers, calcium channel blockers, angiotensin-converting enzyme [ACE] inhibitors, aldosterone receptor blockers) and tricyclic antidepressants (e.g., amitriptyline, nortriptyline) have been used “off-label” in CM prevention.