Again, significant differences were observed between control group and AKI patients for RBP4 and KNG1 (Fig. 2) in the first 48 h and follow-up, confirming previously observed trends by differential gel electrophoresis (DIGE) and the response of these two proteins (RBP4 increase and KNG1 decrease) to AKI. This evidence concerns the gene KNG1 and acute kidney injury.