Experimental and clinical evidence implicates a clear role of the LP in the progression of brain damage in stroke, and the data are consistent with an association of LP activation with unfavorable outcome [1, 14, 15, 17–19], with a few studies highlighting MBL [20, 21] and ficolin-3 [1] as independent predictors of outcome after ischemic stroke. The gene discussed is FCN3; the disease is stroke disorder.