The optimal cut-off value of ficolin-1 as a diagnostic marker of stroke was projected to be 0.25 μg/ml, which yielded a sensitivity of 87 % and a specificity of 84 %; at this cut-off, the odds ratio (OR) was 35.19 [95 % confidence intervals (CI 95 %) 13.63–90.86, p < 0.0001]. This evidence concerns the gene FCN1 and Stroke.