Conversely, expressing a constitutively activated form of Drosophila JAK kinase (hopTum−l) promotes Madm nuclear translocation and suppresses vn and integrin expression in CySCs, allowing GSCs to outcompete CySCs in niche occupancy and promoting GSC tumour formation (Fig. 7e and Supplementary Fig. 14c). This evidence concerns the gene VTN and neoplasm.