Conversely, expressing a constitutively activated form of Drosophila JAK kinase (hopTum−l) promotes Madm nuclear translocation and suppresses vn and integrin expression in CySCs, allowing GSCs to outcompete CySCs in niche occupancy and promoting GSC tumour formation (Fig. 7e and Supplementary Fig. 14c). The gene discussed is NRBP1; the disease is neoplasm.