An substudy of RE-LY (Randomized Evaluation of Longterm anticoagulant TherapY) regarding the prognostic value and risk stratification of biomarkers in AF has indicated an interesting use of cardiac biomarkers.21 They have indicated that serial high levels of cardiac troponin I (cTnI) and N Terminal-pro Brain Natriuretic Peptide (NT-proBNP) are associated with high incidence of stroke and systemic embolism (HR 4.54) and vascular death (HR 8.62). Here, TNNI3 is linked to Stroke.