Compared to normal breast tissue samples, HP1α-V3 mRNA expression was higher in both primary carcinoma samples from patients with lymph node metastasis (1.75-fold, P < 0.0001) and without lymph metastasis (2.02-fold, P < 0.0001) (Fig. 6b). The gene discussed is CBX5; the disease is metastatic malignant neoplasm in the lymph nodes.