For the expression ratio between HP1α-V3 and hnRNPA1, we observed an increase between normal breast tissue and primary carcinoma samples both from patients without metastasis (1.46-fold, P < 0.0001) and patients with metastasis (1.79-fold, P < 0.0001) (Fig. 6c). The gene discussed is CBX5; the disease is carcinoma.