Pmd1 is the fission yeast homolog of the human ATP-binding cassette (ABC) transporter permeability glycoprotein (P-gp/MDR1/ABCB1)25 and we have previously shown that Pmd1 acts synergistically with the vacuolar-ATPase pathway to govern doxorubicin hypersensitivity in human cervical carcinoma cells, probably via modulation of the intracellular accumulation of doxorubicin25. The gene discussed is ABCB1; the disease is cervical carcinoma.