What’s more, univariate analysis demonstrated that HOXA1-and cyclin D1-positive patients exhibited a much higher HR for OS (9.06 vs 1.62) and DFS (8.50 vs 1.58) than HOXA1-or cyclin D1-positive patients, indicating that the combination of HOXA1 and cyclin D1 may better prognosticate clinical outcome for GC. The gene discussed is CCND1; the disease is gastric cancer.