Compared with the OVA-specific memory CD8+ T cells from Wt donors, we observed that memory T cells from Cd28−/− or Ox40−/− donors had significantly reduced upregulation in the mRNA expression of c-Myc and Nfkb1 at day 35 post-infection of VV-OVA (figure 2b). The gene discussed is CD28; the disease is infection.