IARS1 and Sepsis: Notably, persistent inflammation with elevated NF-κB levels even 1 week after recovering from sepsis along with functional mobility defects including impaired geotaxis; sustained transcription of IIR signaling pathway components (InR, IRS, Akt, and mTORC1), impaired glucose metabolism, increased lactate production and LDH activity; and a shorter lifespan in flies surviving sepsis compared to sham [2, 5, 13].