DUSP6 and leukemia: Interestingly, while the myeloid progenitors transformed with BCR-Abl1 showed a higher colony forming ability in the absence of DUSP6/MKP-3, indicating a tumour suppressor function, the colony formation of DUSP6−/− B cell lineage leukaemia was significantly reduced, consistent with a positive role for this phosphatase in malignant transformation.