Furthermore, the growth of pre-B cells transduced with BCR-Abl in the presence of Imatinib was strictly dependent on DUSP6 after washing out the inhibitor, again showing that pre-B ALL cells are dependent on robust DUSP6/MKP-3-mediated negative feedback control of ERK signalling for continued growth and survival [32]. The gene discussed is DUSP6; the disease is acute lymphoblastic leukemia.