Overexpression of DUSP6 has also been identified in a subset of mouse melanoma cell lines, where it is associated with enhanced anchorage-independent growth and invasive capacity [30] and overexpression of DUSP6/MKP-3 in papillary thyroid carcinoma (PTC) cell lines is associated with increased cell migration and invasion [31]. This evidence concerns the gene DUSP6 and differentiated thyroid carcinoma.