This study shows an unexpected convergence of ERK and Akt signalling in the regulation of Ets1 and its target genes including DUSP6/MKP-3 and demonstrates that loss of DUSP6/MKP-3 plays a key role in reinforcing the increased ERK signalling that is coupled to cell survival in the face of specific EGFR inhibitors in NSCLC [48]. This evidence concerns the gene EGFR and non-small cell lung carcinoma.