Such an acquisition to express TLR7 mRNA and, in turn, respond to R837, was suggested to be caused by the presence of type I IFN in SLE serum, also because, in vitro, 1000 U/ml IFNα were shown to induce TLR7 mRNA expression in neutrophils from healthy donors25. Here, IFNA1 is linked to systemic lupus erythematosus.