In the same study, IRS-661 (a specific TLR7 inhibitor) was found to inhibit the upregulation of CD83 in plasmacytoid dendritic cells (pDCs) treated with supernatants harvested from SLE neutrophils previously incubated with anti-ribonucleoprotein antibodies, the latter being shown to trigger neutrophil extracellular trap release via TLR725. The gene discussed is TLR7; the disease is systemic lupus erythematosus.