FNDC5 and diabetes mellitus: Further adjustment of HOMA-B % [OR (95 % CI); 0.55 (0.41–0.75), P < 0.001; model V] or HOMA-IR [OR (95 % CI); 0.66 (0.49–0.90), P < 0.01; model VI] did not affect this association between serum irisin and pre-diabetes/T2D (Table 4).