APOA4 and amyloidosis: Based on the fact that affected patients with amyloidosis also displayed hypotriglyceridemia and increased plasma levels of HDL-C as compared with non-carriers in the family (Table 1), we next screened several candidate genes including the APOC3, APOC1, APOC2, APOC4, APOA4, APOA5 and APOE genes.