Based on the fact that affected patients with amyloidosis also displayed hypotriglyceridemia and increased plasma levels of HDL-C as compared with non-carriers in the family (Table 1), we next screened several candidate genes including the APOC3, APOC1, APOC2, APOC4, APOA4, APOA5 and APOE genes. This evidence concerns the gene APOC1 and amyloidosis.