SASP factors involving interleukins (IL-6, IL-8), growth factors (HGF), secreted proteases (MMP3) which turn senescent cells into pro-inflammatory cells can affect tissue microenvironments and stimulate tumor progression by promoting the proliferation and tumorigenesis of epithelial cells, stimulating angiogenesis, triggering an epithelial to mesenchymal transition, accelerating the invasion of transformed cells[26]. The gene discussed is HGF; the disease is neoplasm.