In the model of acute silicosis used herein, dasatinib improved lung mechanics and led to a reduction of fraction area of granuloma, neutrophils in lung tissue and granuloma, M1 macrophages in lung parenchyma and granuloma, fraction area of collapsed alveoli, collagen fiber content in lung parenchyma, protein levels of IL-1β, TNF-α, and TGF-β, and increased M2 macrophages in lung parenchyma and granuloma. Here, TNF is linked to silicosis.