CRYAB and hepatocellular carcinoma: Furthermore, the up-regulation of Cryab expression seems to be associated with oncogenic transformation in basal-like breast cancer, and induces hepatocellular carcinoma cells epithelial-mesenchymal transition [9], In addition, the high level of Cryab was reported to be associated with cell apoptosis resistance, enhance cell survival under the oncogenic stress, growth factor starvation, chemotherapy, and other cellular stressors [12].