MUC1 and neoplasm: Winn assays [60] further demonstrated that lysate-sensitized T-cells from hyperimmunized MUC1.Tg mice were as ineffective as naïve T-cells for controlling directly admixed MUC1+ tumor challenges, even though the MUC1-hyperimmune T-cells provoked down regulation of tumor MUC1 and H-2Kb (Fig 7B and 7C).