LEMD2 and cataract: LEMD2 c.T38G cosegregated perfectly with the cataract phenotype in a total of 84 individuals from four Hutterite families (Fig. 5); it is homozygous in 17 of 17 individuals with cataracts, heterozygous in 22 of 22 obligate carriers, and heterozygous or absent in 45 of 45 remaining family members (LOD = 9.62; one monozygotic twin pair is counted as a single birth/individual).