EP300 and preeclampsia: 2015; Solomon et al. 2015). However, in our cohort of CREBBP mutation‐positive patients, three out of eight mothers had preeclampsia. Our cohort is relatively small and the information was only available for eight of the mothers, but it gives rise to the question if it is rather the general RTS characteristics of the fetus that may be associated with the preeclampsia than specifically the EP300 mutations.