Nevertheless, the decrease in the total clearance (CLT) of PAH might be justified on one hand by the decreased PAH uptake in renal basolateral membranes and on the other hand by the fact that Oat1 and Oat3 mediate the uptake of a number of As3+- or Hg2+-thiol conjugates [31, 35]. Here, SLC22A8 is linked to pulmonary arterial hypertension.