In summary, we have demonstrated the presence of a positive prostate cancer risk association for COX-2 (-1195G>A) polymorphism, a negative risk association for NFKB1-94 ins/del polymorphism, and absence of association for PPARG Pro12Ala polymorphism, NFKBIA-826C/T polymorphism, and COX-1 (50C>T) polymorphism. Here, PTGS1 is linked to Familial prostate cancer.