In the subgroup of patients with diabetes [15, 16, 26], the data showed that the differential of HDL-C in the ICO group was less than that in the GLU group (P = 0.002) (Table 6) and insulin levels in the ICO group were lower than those in the GLU group (P = 0.01) (Supplemental Table  4). This evidence concerns the gene INS and diabetes mellitus.