As mentioned above, Miyazaki et al. [101] detected abundant levels of ZNF423 transcript in patients with CML blast crisis, but not in those in chronic phase; more recently, a gene profiling analysis of human B-ALLs detected aberrant expression of ZNF423 in most of the cases studied and established a significant correlation between high expression levels and adverse outcome in ETV6-RUNX1-negative B-ALLs [78]. Here, ZNF423 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.