Alternatively, aberrant expression of ZNF423 in LICs may result from copy number gain, secondary to genomic instability caused by ROS-induced oxidative DNA damage, as observed by Bolton-Gillespie et al. [114] in a murine model of imatinib-refractory CML. This evidence concerns the gene ZNF423 and chronic myelogenous leukemia, BCR-ABL1 positive.