CTLA4 and cancer: Thus, “activation” markers, such as CD39, CTLA-4, latency-associated peptide (LAP), glycoprotein A repetitions predominant (GARP), PD-1, PD-L1 and others that are often overexpressed on Treg in cancer, emerge as important surrogate markers for Treg function and should be included in the monitoring of Treg in cancer patients.