Platelet-derived growth factor (PDGF) is strongly associated with VEGF pathway, and it is involved in cell migration during vascular development. In vivo and in vitro studies showed that activating mutations of PDGF receptor (PDGFR) in embryo promote vascular development; instead PDGF antagonists inhibit vasculogenesis and tumor growth in rat model [43]. The gene discussed is VEGFA; the disease is neoplasm.