The obesity-associated allele of SNP rs8051036 has been suggested to decrease RPGRIP1L expression via reduced affinity for a transcriptional activator [26]. IRX3 expression has recently been documented to account for the obesity association with FTO SNPs in human cerebellar tissue [28] and in the pancreas in zebrafish [30]. This evidence concerns the gene RPGRIP1L and obesity due to melanocortin 4 receptor deficiency.