We found that some of the receptors were differentially expressed during all or most pneumococcal infections regardless of their clinical outcome (e.g., Cxcl1, IL13RA1, Ccl19, IL1A, and IL1B), many were identified in a few tested infections (without a clear association with animal survival), and only one gene was found uniquely in nonlethal infections: CSF2RA (involved in pulmonary surfactant metabolism). Here, CSF2RA is linked to pneumococcal infection.