Nuclear transport and presence of IF proteins has been demonstrated for tail-less cytokeratin 8, 18, and 19 in 3T3 fibroblasts (Bader et al., 1991), for vimentin in nasopharyngeal carcinoma lymph node metastasis (Luo et al., 2012), for nestin in various brain tumors (Krupkova et al., 2011), and for desmin in BHK21 cells (Kamei, 1986). The gene discussed is NES; the disease is brain neoplasm.