NKX2-5 and congenital heart disease: Cardiomyogenesis is severely hampered when Nkx2.5 is mutated or absent in vertebrates (Bodmer, 1993; Bruneau et al., 2000; Chen and Fishman, 1996; Kasahara et al., 2000), and mutant Nkx2.5 cause severe congenital heart diseases in humans (Reamon-Buettner and Borlak, 2010).