TNKS and lung carcinoma: To provide proof of concept that TNKS/2 blockade was proficient in lung cancer, A549 cells were treated with increasing concentrations of XAV939 or JNJ-BJ for 24 h and assessed for expression of axin1, which is typically stabilized by TNKS/2 inhibition owing to impaired TNKS/2-mediated PARsylation and consequent protein degradation [12].