One example of an epigenetic mechanism is that uteroplacental insufficiency-induced intrauterine growth restriction (IUGR), which predisposes to adult-onset insulin resistance, decreases postnatal insulin-like growth factor-1 (IGF-1) mRNA variants and the gene elongation mark histone 3 trimethylation of lysine 36 of the IGF-1 gene (H3Me3K36). This evidence concerns the gene IGF1 and Insulin resistance.