ALOX12B and autosomal recessive congenital ichthyosis: Autosomal recessive congenital ichthyosis is also triggered by the mutations in ALOX12B or ALOXE3 genes, encoding the lipoxygenases 12R-LOX and epidermal LOX-3, respectively, which are both involved in the transformation of fatty acid substrates to epoxy alcohol derivatives and play an important role in the barrier function of epidermis.