CASP3 and neoplasm: Then we examined the effect of AZD3463 on the PI3K/AKT/mTOR signaling in the tumor tissues and found that AZD3463 efficiently blocked Akt and RPS6 phosphorylation and induced the cleavage of PARP, caspase 3, and LC3 A/BΙΙ (Fig. 5E) in vivo.